IB Project details
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| IB Project: Membrane Receptors on Platelets and Endothelial Cells Involved in Thrombosis | ||
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| Faculty: Medicine - UMCU | Department: Clinical Chemistry and Haematology - UMCU | Click to see website |
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| IB Staff:
(IB contact) Prof.dr. Jan Willem Akkerman j.w.n.akkerman@umcutrecht.nl Tel: +31 (0)88 75 7769 |
PhD Student(s): Drs. Mirjam Meltzer m.e.meltzer@umcutrecht.nl |
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| IB Staff:
Dr. Barend Bouma b.bouma@umcutrecht.nl Tel: +31 (0)88 755 7769 |
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| IB Staff:
Dr. Rob Fijnheer r.fijnheer@umcutrecht.nl Tel: +31 (0)88 755 7769 |
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| IB Staff:
Dr. Martijn Gebbink m.gebbink@umcutrecht.nl Tel: +31 (0)88 755 7769 |
PhD Student(s): Drs. Coen Maas cmaas4@umcutrecht.nl |
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| IB Staff:
(IB board) Prof.dr. Flip de Groot ph.g.degroot@umcutrecht.nl Tel: +31 (0)88 755 7769 |
Postdoc(s): Dr. Martine Hollestelle m.j.hollestelle@umcutrecht.nl |
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| IB Staff:
Dr. Harry Heijnen h.f.g.heijnen@umcutrecht.nl Tel: +31 (0)88 755 7769 |
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| IB Staff:
Dr. Mark Roest m.roest@umcutrecht.nl Tel: +31 (0)88 755 7769 |
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| IB Staff:
Dr. Ron Voorbij r.voorbij@umcutrecht.nl Tel: +31 (0)88 755 7769 |
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| IB Staff:
Dr. Richard van Wijk r.vanwijk@umcutrecht.nl Tel: +31 (0)88 755 7769 |
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| Available techniques, facilities and expertise: 1 Aggregometer |
Contact and or Remarks: Clotting assays. Clinical Chemistry and Haematology |
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| 2 ELISA (commercial) ELISA (in house) | Diagnostic tool Investment in 6 markers, 2 semi-automatic robots available. Clinical Chemistry and Haematology. Very sensitive method. In house ELISA is less expensive than kit. | |
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| 3 Immuno Electron microscopy | Both TEM and SEM for cell and vessel imaging. Cell Biology UMCU Immuno EM also provides information about protein localization besides morphology. | |
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| 4 Perfusion model &Interference reflection contrast microscopy | Cell imaging, e.g. study platelet binding using a flow system. Collaboration. | |
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| 5 Proteomics | To analyze platelets reactivity upon external stimuli, find biomarkers European cooperation | |
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| 6 SNP analysis | Detect effect of single nucleotide polymorphism on gene product. Collaboration Immunology UMCU | |
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| 7 Time lapse / video microscopy | Cell imaging, e.g. formation of platelets in the bone marrow. Clinical Chemistry and Haematology. | |
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| 8 X-ray crystallography | To study protein structure and interaction sites. Cooperation P. Gros – Crystal and structural Chemistry. Not always possible to obtain (good) crystals or of the complete protein. Also time consuming. | |
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