IB Project details
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| IB Project: Chemical Biology | ||
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| Faculty: Science - Dept. of Chemistry | Department: Chemical Biology | Click to see website |
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| IB Staff:
Dr. Eefjan Breukink e.j.breukink@uu.nl Tel: +31 (0)30 253 3523 |
PhD Student(s): MSc. Paulien Van Bentum P.T.vanBentum@uu.nl Drs. Diana Stork d.stork@uu.nl MSc. Remko van Vught r.vanvught@uu.nl |
Postdoc(s): Dr. Tami Mohammadi t.mohammadi@uu.nl (non-IB participant) Drs. Yvonne te Welscher y.m.tewelscher@uu.nl (non-IB participant) |
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| IB Staff:
(IB board) Prof.dr. Antoinette Killian j.a.killian@uu.nl Tel: +31 (0)30 253 3442 |
PhD Student(s): MSc. Jacques Doux j.p.f.doux@uu.nl (non-IB participant) Drs. Erica Kremer e.c.e.kremer@uu.nl Drs. Tania Rutters-Meijneke t.meijneke@uu.nl (non-IB participant) |
Postdoc(s): Dr. Sylvestre Bonnet s.a.bonnet@uu.nl (non-IB participant) |
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| IB Staff:
(IB contact) Prof.dr. Ben de Kruijff b.dekruijff@uu.nl Tel: +31 (0)30 253 1607 |
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| Available techniques, facilities and expertise: 1 Advanced biophysical techniques and molecular biology |
Contact and or Remarks: |
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| 2 Atomic Force Microscopy (AFM) | Drs. D.N. Ganchev http://cble.chem.uu.nl/biomem/dragomir.htm | |
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3 Circular Dichroism (CD)
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Dr. Maarten Engel, to analyze secondary structure of proteins http://cble.chem.uu.nl/biomem/maarten.htm | |
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| 4 Differential scanning calorimetry | to analyze the energy of interactions | |
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| 5 Differential Scanning Calorimetry (DSC) | Ing. M.C. Koorengevel http://cble.chem.uu.nl/biomem/martijn.htm | |
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| 6 Fluorescence microscopy | ||
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| 7 GUV = Giant Unilamellar Vesicle | to study membrane-protein interactions | |
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| 8 Infrared spectrometry | ||
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9 Isothermal Titration Calorimetry (ITC)
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Dr. Eefjan Breukink e.j.breukink@uu.nl to detect protein-protein (or protein lipid interactions) | |
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| 10 LUV = Large Unilamellar Vesicle | to study membrane-protein interactions | |
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11 Mass spectrometry
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| 12 Membrane NMR | Prof.dr. Antoinette Killian j.a.killian@uu.nl | |
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| 13 Micelles | to study membrane-protein interactions | |
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| 14 MLV = Multi Lamellar Vesicle | to study membrane-protein interactions | |
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| 15 Model peptide synthesis WALP | ||
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| 16 Model systems | ||
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| 17 Monolayer technique | to analyze insertion of peptides into a lipid monolayer | |
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| 18 Monolayer techniques | Ing. R.W.H.M. Staffhorst http://cble.chem.uu.nl/biomem/rutger.htm | |
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| 19 Mutagenesis studies | for interaction studies | |
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| 20 NMR to detect changes in bilayer thickness | ||
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| 21 Particle analyzer | Ing. R.W.H.M. Staffhorst http://cble.chem.uu.nl/biomem/rutger.htm | |
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| 22 Preparation of model membranes | Dr. Toon de Kroon a.i.p.m.dekroon@uu.nl | |
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| 23 SUV = Small lamellar Vesicle | to study membrane-protein interactions | |
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| 24 X-ray diffraction | ||
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