IB Course 2010

March 22-March 26

Participation in this course is obligatory for all new graduate students who have been appointed in one of the IB-research groups. Post docs who have recently entered the IB are encouraged to participate, but their participation is not obligatory. The course is open for master students in BioMolecular Science (BMS) as well (This year only a limited amount will be accepted).

The course will be organised along the four IB research themes. IB specialists in these fields will give an introduction to the field as well as insights into the current developments. In addition, IB guest speakers will present their work in IB seminars that will be discussed in more detail during the course. During the course, main facilities of the IB will be visited.

Archive for the programs:
Program IB Course 2009
Program IB Course 2008
Program IB Course 2007
Program IB Course 2006

Biogenesis, Translocation & Sorting (BTS)

• Mechanisms of protein- and lipid-insertion in-, and translocation through membranes in prokaryotic and eukaryotic cells (included are cytoplasmatic- and outer-membranes, ER, mitochondria, or chloroplasts).
• Biogenesis of membrane-, secretion- and organelle-proteins (included are aspects like folding, co- and post-translational modifications, and the assembly in macro molecular complexes).
• Mechanisms of addressing, sorting, transport and translocation of proteins and lipids in the cell.

Membrane proteins (MP)

• Structural and topographic analysis of membrane-proteins/enzymes, by way of Roentgen-analysis, EM, and chemical- and genetic techniques.
• How do these proteins work (biochemical characterization, ligand-binding sites, specificity).
• Regulation of membrane protein functions by way of membrane structure/-components (effects of membrane lipids/lipid-organization on the activity of membrane enzymes and / or the characteristics of membrane proteins).

Signal transduction (ST)

Localization and function of:

• Membrane-associated proteins like phospholipases, kinases, receptors and pore- and transport proteins.
• Signal transduction components, like ras, MAP-kinase, etc.
• Phospholipid transport proteins.
• Cell cycle regulation: cdk’s, cyclines, etc.

Vascular Membrane Biology (VMB)

• Cardiovascular risk factors (hypertension, uremia) and endothelial cell function and the role of progenitor cells.
• Aging of the vessel wall and endothelial cells by way of genomics, proteomics, electron microscopy and cell biological techniques.
• Interaction between haemostatic proteins and cell surface receptors on platelets, blood cells and endothelial cells, implications for haemostasis and thrombosis.