Patrice Codogno

Institute:Research Center on Growth and Signaling
Title:When autophagy meets primary cilium
Abstract:["Autophagy is a cellular catabolic process that contributes to quality control through the turnover of proteins and organelles in lysosomes. This form of lysosomal degradation also participates in the maintenance of the cellular energetic balance by providing free amino acids and fatty acids when nutrients are scarce. Induction of autophagy initiates the formation of autophagosomes, double-membrane vesicles that sequester cytoplasmic material and deliver it through vesicular fusion to lysosomes for degradation.

Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia, a non-motile signaling organelle that grows in a specific region of the plasma membrane of almost all cell types. The recently discovered role of primary cilia in nutrient sensing and signaling motivated us to explore the possible functional interactions between this signaling hub and autophagy."]
Host:Fulvio Reggiori - (0)88 755 6551