Robert Ernst

Institute:Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg
Title:Lipid fingerprints of a stressed cell - The unfolded protein response and lipid bilayer stress
Abstract:["Biological membranes are complex assemblies of proteins and lipids and their homeostasis is crucial for life. We are interested in the crosstalk between protein homeostasis and lipid metabolism at the molecular and the cellular level. The significance of this connection is underscored by the fact that most diseases related to protein misfolding also have specific lipid signatures. The role of lipids in the pathogenesis of these diseases and the underlying mechanisms remain poorly understood. The unfolded protein response (UPR) is a central homeostatic program regulating the expression of more than 5% of all genes in S cerevisiae. The UPR of mammals is more complex and active in every secretory cell. Professional secretory cells such as antibody producing plasma cells or insulin producing \u03b2-cells are particularly dependent on the UPR to cope with high secretory demand. Originally identified as stress response to accumulating unfolded proteins in the lumen of the ER, it is now accepted that aberrant lipid compositions are equally potent activators of the UPR. Here, we describe the molecular mechanism underlying the activation of the UPR by lipid bilayer stress."]
Host:Toon de Kroon - (0)30 253 3424