Seminars 2010

Date Speaker Seminar Title Host Abstract
11-01-2010 Ana Maria Cuervo
Dept. of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, USA
Selective Autophagy: cleaning and fueling old cells Fulvio  Reggiori
[(0)88 755 6551]
Autophagy is the intracellular process that mediates the digestion of cellular components in lysosomes. The autophagic system fulfills two major functions in mammalian cells, servi … read more
21-01-2010 Patrick Williamson
Amherst College, USA
Sinking the life raft: Apoptosis and Plasma Membrane Structure Joost  Holthuis
[(0)30 253 6630]
19-02-2010 Michael Schwake
Unit of Molecular Cell Biology and Transgenic Research, Christian Albrechts University Kiel, Germany
New insights into the lysosomal transport of ß-glucocerebrosidase Judith  Klumperman
[(0)88 755 6650]
Recent Key publications:

Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand beta-gluco … read more

16-03-2010 Antonio Moschetta
Laboratory of Lipid Metabolism and Cancer, University of Bari, Italy
Intestinal Specific Activation of Nuclear Receptor LXR Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis Bernd  Helms
[(0)30 253 5375]
Several steps of the HDL-mediated reverse cholesterol transport (RCT) are transcriptionally regulated by the nuclear receptors LXRs in the macrophages, liver and intestine. Systemi … read more
26-03-2010 Miguel Penalva
Centro de Investigaciones Biológicas CSIC, Madrid, Spain
Endocytic and secretory membrane traffic during persistent apical extension in Aspergillus nidulans Fulvio  Reggiori
[(0)88 755 6551]
16-04-2010 Jeroen van de Water
Molecular Neurotherapy and Imaging Laboratory, Harvard Medical School, Boston USA
Stem cell-delivered immunotherapy for glioblastoma: The potential of anti-EGFR nanobodies and their variants Paul van Bergen en Henegouwen
[(0)30 253 3349]

Specifically targeted therapeutic agents combined with innovative modes of delivery, non-invasive imaging of drug delivery and efficacy are crucial in develop … read more

23-04-2010 Stefan Höning
Institute of Biochemistry, University of Koln
PtdIns4,5P2 is a key regulator for membrane recruitment and cargo binding of the AP2 clathrin adaptor complex Rob  Mesman
[(0)30 253 3477]
The AP2 adaptor complex (222 subunits) crosslinks the endocytic clathrin scaffold to PtdIns4,5P2-containing membranes and tr … read more
21-05-2010 Hesso Farhan
Biozentrum, University of Basel, Switzerland.
Regulation of architecture and function of the secretory pathway by signal transduction Catherine  Rabouille
[(0)30-2121 941]
To what extent the secretory pathway is regulated by cellular signaling is unknown. Here, we used RNA interference to explore the function of human kinase … read more
04-06-2010 Jesse Hay
Div. of Biological Sciences & Center for Structural and Functional Neuroscience, The U. of Montana
Mechanisms of ER to Golgi Transport: Luminal Calcium, Vesicle Coats, SNAREs, and Neurodegeneration Judith  Klumperman
[(0)88 755 6650]
This IB seminar will describe the highlights of two projects investigating molecular mechanisms in ER-to-Golgi vesicle trafficking:
1) Potential roles of lumina … read more
08-06-2010 Bill Skach
Division of Hematology and Medical Oncology, Oregon Health & Science University, USA
Spectroscopic analysis of nascent protein folding on (and off) the ribosome Ineke  Braakman
[(0)30 253 2759]
11-06-2010 Andreas Conzelmann
University of Fribourg, Department of Medicine, Division of Biochemistry
Biosynthesis, turnover and function of sphingolipids in the yeast Saccharomyces cerevisiae Gerrit van Meer
[(0)30 253 3427]
In yeast inositolphosphorylceramides (IPCs) mostly contain C26:0 fatty acids and were considered to be important for viability, since the IPC synthase AUR1 is essential. lcb1∆ … read more
18-06-2010 Sebastian Springer
Biochemistry and Cell Biology Jacobs University Bremen, Germany
MHC class I: ligand binding, quality control, and ER-Golgi transport Ineke  Braakman
[(0)30 253 2759]
10-09-2010 Satyajit Mayor
National Centre for Biological Sciences, Bangalore, India;
Gerrit van Meer
[(0)30 253 3427]
Active remodeling of cortical actin regulates spatiotemporal organization of cell surface molecules : a new paradigm for the construction of membrane domains in living cell membran … read more
15-09-2010 Stuart Kornfeld
Washington University School of Medicine, St. Louis, Missouri
New insights into the Man-6-P lysosomal targeting system Judith  Klumperman
[(0)88 755 6650]
We are studying the biochemical and molecular basis for protein trafficking in mammalian cells, focusing on the biogenesis of lysosomes. The targeting of lysosomal enzymes from the … read more
19-11-2010 Cristina Risco
National Research Counsel of Spain, CSIC, Madrid
Studying virus factories and cell architecture with new high resolution imaging techniques Raoul de Groot
[(0)30 253 1463]
Viruses are genetically simple associations of macromolecules that exhibit a variable complexity from a structural point of view. Complex, enveloped viruses, some of them important … read more
26-11-2010 Dimitrios Stamou
Dept. of Neuroscience and Pharmacology, and Nano-Science Center, University of Copenhagen, Denmark
Nanoscale membrane-curvature as an allosteric modulator of protein localization and function Gerrit van Meer
[(0)30 253 3427]
To date we have established exhaustive correlations between the lipid composition of membranes and its impact on membrane properties and protein function. In addition to compositio … read more
Posted in Seminars archive